Asymmetric synthesis of N-stereogenic molecules: diastereoselective double aza-Michael reaction.
نویسندگان
چکیده
A novel approach towards the asymmetric synthesis of N-stereogenic molecules via double aza-Michael addition was developed. The diastereomeric ratio can be increased by a thermodynamically controlled isomerization mechanism. Simple separation and functionalization of the products afford N-stereogenic compounds in high enantiomeric purity.
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عنوان ژورنال:
- Chemical communications
دوره 50 10 شماره
صفحات -
تاریخ انتشار 2014